≥99%
221231-10-3
1815.08 g/mol
Peptides. Deep Dive
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AOD-9604
How aod-9604 works in research
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AOD-9604
A modified fragment of human growth hormone (hGH 177-191) studied for fat metabolism.
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Peptides. Deep Dive
Research-based Podcast
AOD-9604
How aod-9604 works in research
An average rating of 4.6/5 from verified customer feedback
Characteristics
| Property | Value |
|---|---|
| Molecular Formula | C₇₈H₁₂₃N₂₁O₂₃S₂ |
| CAS Number | 221231-10-3 |
| Molar Mass | 1815.08 g/mol |
| Amino Acid Sequence | Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (hGH 176-191) |
| Synonyms | hGH Fragment 176-191, Anti-Obesity Drug 9604, AOD9604, Tyr-hGH 177-191 |
| Physical Form | Lyophilized powder |
| Solubility | Soluble in water and dilute acetic acid |
| Organoleptic Profile | White lyophilized powder; odorless |
| Storage Conditions | Store lyophilized at -20°C; reconstituted solution stable at 2-8°C |
| Composition | Lyophilized hGH fragment 176-191 acetate salt |
How is AOD-9604 Used in Research?
AOD-9604 is a modified fragment of growth hormone (hGH) encompassing amino acids 176-191 from the C-terminal region, with an added tyrosine residue at the N-terminus. This fragment was isolated based on research identifying the lipolytic domain of growth hormone as distinct from its growth-promoting and diabetogenic regions. The peptide retains the fat-metabolizing activity attributed to the full hGH molecule while lacking the growth-promoting effects mediated by IGF-1, making it a subject of research into targeted fat metabolism modulation.
Preclinical studies in obese animal models have demonstrated that AOD-9604 stimulates lipolysis (fat breakdown) and inhibits lipogenesis (fat formation) without affecting blood glucose or tissue growth. The mechanism is believed to involve activation of beta-3 adrenergic receptor-mediated pathways in adipose tissue, mimicking the lipolytic cascade triggered by growth hormone without the associated insulin resistance. Research by Heffernan et al. demonstrated that chronic administration in obese Zucker rats produced significant reductions in body fat mass without changes in lean body mass or food consumption.
Additional research has explored AOD-9604's potential in cartilage repair and regeneration. Studies have reported that the peptide may stimulate proteoglycan and collagen synthesis in chondrocytes, leading to investigation of its potential in cartilage regeneration models.
This product is supplied in a lyophilized form and requires reconstitution prior to laboratory handling. For research and laboratory use only. Not for human or veterinary consumption.
Areas of Study
Lipolysis & Fat Metabolism
Investigated for stimulation of lipolysis and inhibition of lipogenesis through beta-3 adrenergic receptor-mediated pathways in adipose tissue.
Weight Management
Studied as a targeted fat metabolism modulator that retains growth hormone's lipolytic activity without IGF-1-mediated growth effects or diabetogenic properties.
Cartilage Repair
Research explores potential stimulation of proteoglycan and collagen synthesis in chondrocytes, relevant to osteoarthritis and cartilage regeneration.
Metabolic Safety Profile
Investigated for its lack of effect on blood glucose, insulin sensitivity, and IGF-1 levels compared to full-length growth hormone.
Adipocyte Biology
Studied for selective effects on adipocyte metabolism, including modulation of fat cell differentiation and lipid storage pathways.
References
- [1]Heffernan MA, Thorburn AW, Fam B, et al. (2001). Increase of fat oxidation and weight loss in obese mice by chronic treatment with human growth hormone or a modified C-terminal fragment. International Journal of Obesity, 25(10), 1442-1449.
- [2]Ng FM, Sun J, Sharma L, et al. (2000). Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Hormone Research, 53(6), 274-278.
- [3]Kwok HH, Mok DK, Chan PH, et al. (2012). Growth hormone fragment 176-191 enhances articular cartilage repair in preclinical models. Osteoarthritis and Cartilage, 20(Suppl 1), S142.
Disclaimer: The information provided is for research reference only and does not constitute medical advice. Products are sold strictly for in-vitro research use.
Certificate of Analysis (COA)
Third-Party Verified Quality
Every batch of AOD-9604is independently tested by an accredited third-party laboratory. Our COAs include HPLC purity analysis, mass spectrometry identity confirmation, and batch-specific lot numbers. We publish these results publicly so you can verify exactly what you're getting.
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